Patents & Publications

ISSUED Patents

Method of enriching stem and/or progenitor cells.
Microfluidic device and method of manufacturing the microfluidic device.
Microfluidic device and method of manufacturing the microfluidic device.


High-Throughput Single Cell Sorting Using Microbubble Well Arrays. (Nidus Filed IP)
High Throughput Cellular Analysis Using Microbubble Arrays.


2017 Mar
Qihui Pu, Ryan Spooner, Lisa A. DeLouise. “Identifying drug resistant cancer cells using microbubble well arrays.” Biomedical Microdevices. Mar. 2017 (online) 19:17
2016 Oct
Chandrasekaran S, Giang UB, Xu L, DeLouise LA. “In vitro assays for determining the metastatic potential of melanoma cell lines with characterized in vivo invasiveness.” Biomedical microdevices. 2016 Oct; 18(5):89.
2014 Sep
Bobo B, Phelan D, Rebhahn J, Piepenbrink MS, Zheng B, Mosmann TR, Kobie JJ, DeLouise LA. “Microbubble array diffusion assay for the detection of cell secreted factors.” Lab on a chip. 2014 Sep 21; 14(18):3640-50. Epub 2014 Jul 31.
2014 Feb
Giang UB, Jones MC, Kaule MJ, Virgile CR, Pu Q, DeLouise LA. “Quantitative analysis of spherical microbubble cavity array formation in thermally cured polydimethylsiloxane for use in cell sorting applications.” Biomedical microdevices. 2014 Feb; 16(1):55-67.
2013 Jun
Jones MC, Kobie JJ, DeLouise LA. “Characterization of cell seeding and specific capture of B cells in microbubble well arrays.” Biomedical microdevices. 2013 Jun; 15(3):453-63.
2012 Dec
Chandrasekaran S, Geng Y, DeLouise LA, King MR. “Effect of homotypic and heterotypic interaction in 3D on the E-selectin mediated adhesive properties of breast cancer cell lines.” Biomaterials. 2012 Dec; 33(35):9037-48. Epub 2012 Sep 17.
2011 Dec
Chandrasekaran S, DeLouise LA. “Enriching and characterizing cancer stem cell sub-populations in the WM115 melanoma cell line.” Biomaterials. 2011 Dec; 32(35):9316-27. Epub 2011 Sep 13.
2011 Oct
Chandrasekaran S, Giang UB, King MR, DeLouise LA. “Microenvironment induced spheroid to sheeting transition of immortalized human keratinocytes (HaCaT) cultured in microbubbles formed in polydimethylsiloxane.” Biomaterials. 2011 Oct; 32(29):7159-68. Epub 2011 Jul 02.
2011 Jun
Agastin S, Giang UB, Geng Y, DeLouise LA, King MR. “Continuously perfused microbubble array for 3D tumor spheroid model.” Biomicrofluidics. 2011 Jun; 5(2):24110. Epub 2011 Jun 03.
U.T. Giang, M.R. King, and L. A. DeLouise. “Microfabrication of Bubbular Cavities in PDMS for Cell Sorting and Microcell Culture Applications.” J of Bionic Eng. 2008; 5(4): 308-16.
2007 Dec
Giang UB, Lee D, King MR, DeLouise LA. “Microfabrication of cavities in polydimethylsiloxane using DRIE silicon molds.” Lab on a chip. 2007 Dec; 7(12):1660-2. Epub 2007 Oct 12.
U. Giang, D. Lee, M. King and L. DeLouise,. “Microfabrication of Concave Cavities in Polydimethylsiloxane Using DRIE Silicon Molds.” Lab Chip. 2007; 7: 1660-62.